Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

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Abstract Background [18F]FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase.This makes [18F]FDG-PET a valuable tool in the diagnostic workup of neurodegenerative diseases.The utility of [18F]FDG-PET in dementia with Lewy bodies (DLB) needs further validation by considering large samples of patients and disease comparisons and applying state-of-the-art statistical methods.Here, we aimed to provide an extensive validation of the [18F]FDG-PET metabolic signatures in supporting DLB diagnosis near the first LIGHT BUCKWHEAT FLOUR clinical assessment, which is characterized by high diagnostic uncertainty, at the single-subject level.Methods In this retrospective study, we included N = 72 patients with heterogeneous clinical classification at entry (mild cognitive impairment, atypical parkinsonisms, possible DLB, probable Record Player with USB Recording DLB, and other dementias) and an established diagnosis of DLB at a later follow-up.

We generated patterns of [18F]FDG-PET hypometabolism in single cases by using a validated voxel-wise analysis (p 90%.Conclusion The present validation of the diagnostic and prognostic accuracy of the disease-specific brain metabolic signature in DLB at the single-subject level argues for the consideration of [18F]FDG-PET in the early phase of the DLB diagnostic flowchart.The assessment of the [18F]FDG-PET hypometabolism pattern at entry may shorten the diagnostic time, resulting in benefits for treatment options and management of patients.